Ebook Handbook of Carbohydrate Engineering

October 4, 2008 by dadmin

The structure, function, and composition of many of the complex carbohydrates found in nature have been described by analytical chemistry and the composition of biosynthetic machinery used to build them has been revealed by advances in genome sequencing. This has set the stage for the active manipulation of carbohydrate structure and intervention in the glycosylation process. The Handbook of Carbohydrate Engineering provides an overview of the basic science, theory, methods, and applications of this broad, interdisciplinary field. It offers a cohesive, coordinated approach to carbohydrate engineering that will serve as an invaluable reference for laboratory researchers and students alike.

Synopsis:
Seventy-seven international researchers contribute 29 chapters providing an up-to-date overview of the basic science, theory, methods, and applications of carbohydrate engineering. Coverage includes the isolation, purification, and structural characterization of carbohydrates; the study of glycosylation in living cells; the exploitation of the "glycosylation machinery" for the production of complex carbohydrates in living cells; cell-free enzymatic methods for carbohydrate synthesis; chemical synthetic methods; industrial and biotechnological applications; applications in biomedicine and human health; and the types of carbohydrates—polysaccharides, oligosaccharides, and monosaccharides. For practicing engineers and students in biology, chemistry, biochemistry, organic chemistry, chemical engineering, industrial research, and food science.

Table of Contents:

Ch. 1 Mammalian glycosylation : an overview of carbohydrate biosynthesis 1
Ch. 2 Patterning of lectins of vero and MDCK cells and influenza viruses : the search for additional virus/cell interactions 49
Ch. 3 O-acetyl sialic acids in parasitic diseases 71
Ch. 4 Congenital disorders of glycosylation 99
Ch. 5 Role of milk carbohydrates in preventing bacterial adhesion 141
Ch. 6 Structural characterization of glycosaminoglycans 177
Ch. 7 Carrageenans : structural and conformational studies 211
Ch. 8 Computational modeling in glycosylation 247
Ch. 9 Biosynthetic pathways for differential expression of functional chondroitin sulfate and heparan sulfate 289
Ch. 10 Large-scale production of oligosaccharides using engineered bacteria 325
Ch. 11 Fructan biosynthesis in genetically modified plants 339
Ch. 12 Chinese hamster ovary (CHO) glycosylation mutants for glycan engineering 371
Ch. 13 Biochemical engineering of sialic acids 387
Ch. 14 Glycosylation in native and engineered insect cells 407
Ch. 15 N-glycan engineering in yeasts and fungi : progress toward human-like glycosylation 431
Ch. 16 Bacterial capsules : a route for polysaccharide engineering 479
Ch. 17 Chemo-biological approach to modification of the bacterial cell wall 495
Ch. 18 Engineering bacterial biopolymers for the biosorption of heavy metals 507
Ch. 19 Treatment of wastewaters with the biopolymer chitosan 535
Ch. 20 The role of glycosylation in engineered antibodies 563
Ch. 21 Recent developments in the synthesis of oligosaccharides by hyperthermophilic glycosidases 587
Ch. 22 Modification of plant cell wall polysaccharides using enzymes from Aspergillus 613
Ch. 23 [beta]-glucosidases from filamentous fungi : properties, structure, and applications 645
Ch. 24 Sialic acids and sialylmimetics : useful chemical probes of sialic acid-recognizing proteins 687
Ch. 25 Engineering carbohydrate scaffolds into the side chains of amino acids and use in combinatorial synthesis 749
Ch. 26 Effects of short- and long-chain fructans on large intestinal physiology and development of preneoplastic lesions in rats 781
Ch. 27 Alginate as a drug delivery carrier 799
Ch. 28 Chitosan-based nonviral vectors for gene delivery 817
Ch. 29 Polysaccharides in tissue engineering applications 837

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